ABSTRACT
Kearns-Sayer syndrome, a rare mitochondrial disorder, is composed of chronic progressive external ophthalmoplegia, atypical retinal pigmentation and complete heart block, and also causes numerous neurologic or endocrinologic symptoms. On muscle biopsy, a "ragged red fiber" was seen with Gomori trichrome stain, On electron microscopy, aggregations of abnormal mitochondria were demonstrated, confirming the diagnosis of mitochondrial myopathy. We report a case of Kearns-Sayer syndrome we have experienced.
Subject(s)
Biopsy , Diagnosis , Heart Block , Microscopy, Electron , Mitochondria , Mitochondrial Diseases , Mitochondrial Myopathies , Ophthalmoplegia, Chronic Progressive External , Pigmentation , RetinaldehydeABSTRACT
Subject(s)
Animals , Cricetinae , 9,10-Dimethyl-1,2-benzanthracene , Carcinogenesis , Carcinoma in Situ , Carcinoma, Squamous Cell , Cytoplasm , Epigenomics , Epithelium , Islands , Mineral Oil , Mouth Neoplasms , Mucous Membrane , Prognosis , Transforming Growth Factor alpha , Transforming Growth Factor beta , Transforming Growth FactorsABSTRACT